Volume 8, Issue 3, May 2020, Page: 31-40
Research Progress on Regulatory T Cell Differentiation and Regulation
Jing Feng, Cangzhou Central Hospital, Cangzhou, China
Zhaoxin Mu, Institute of Thyroid Diseases Affiliated to Cangzhou Medical College, Cangzhou Thyroid Disease Engineering Technology Research Center, Cangzhou, China
Zhenjiang Hou, Institute of Thyroid Diseases Affiliated to Cangzhou Medical College, Cangzhou Thyroid Disease Engineering Technology Research Center, Cangzhou, China
Received: Apr. 10, 2020;       Published: Jun. 8, 2020
DOI: 10.11648/j.ajcem.20200803.11      View  265      Downloads  92
Abstract
Regulatory T cells (Treg) are a subset of T cells with immunosuppressive functions. According to the source and mechanism of Treg cells, they are divided into natural regulatory T cells (nTreg) and induced regulatory T cells (iTreg). According to the different properties of secreted cytokines, they are divided into two types: pro-inflammatory and anti-inflammatory cells. Pro-inflammatory Treg cells that secrete IFN-ã are closely related to the development of autoimmune diseases, while anti-inflammatory Treg cells that secrete IL-10 can reduce the development of slow inflammation. In addition to secreting a variety of inhibitory cytokines such as IL-10 and TGF-â, Treg cells also exert immunosuppressive effects through direct contact among cells to jointly maintain the body's immune tolerance and suppress immune responses. By suppressing the autoimmune response of effector T cells and promoting immune tolerance, it has a very important role in maintaining the homeostasis of the body. The differentiation and regulation of Treg cells and their relationship with autoimmune diseases have been hotspots in the field of immunology in recent years. This article reviews the source of Treg, differentiation regulation, classification, markers, functions and mechanisms of action so as to deepen the understanding of Treg cell differentiation and immune regulation mechanisms, and further broaden the research horizon and thinking.
Keywords
Regulatory T Cells, Cluster of Differentiation 4+T Cells, Interleukin-10, Transforming Growth Factor-β, Forkhead Box p3, Signal Transduction and Activator of Transcription
To cite this article
Jing Feng, Zhaoxin Mu, Zhenjiang Hou, Research Progress on Regulatory T Cell Differentiation and Regulation, American Journal of Clinical and Experimental Medicine. Vol. 8, No. 3, 2020, pp. 31-40. doi: 10.11648/j.ajcem.20200803.11
Copyright
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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